Subject(s)
COVID-19/prevention & control , ChAdOx1 nCoV-19/adverse effects , Necrosis/diagnosis , Skin Diseases/pathology , Thrombosis/diagnosis , Administration, Topical , Aged , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/therapeutic use , Anti-Inflammatory Agents/administration & dosage , Anti-Inflammatory Agents/therapeutic use , Biopsy , COVID-19/diagnosis , COVID-19/epidemiology , COVID-19/virology , Clobetasol/administration & dosage , Clobetasol/therapeutic use , Combined Modality Therapy , Compression Bandages , Diagnosis, Differential , Humans , Male , Necrosis/drug therapy , Necrosis/therapy , Neomycin/administration & dosage , Neomycin/therapeutic use , Nystatin/administration & dosage , Nystatin/therapeutic use , SARS-CoV-2/genetics , SARS-CoV-2/immunology , Skin/pathology , Skin Diseases/chemically induced , Thrombosis/drug therapy , Thrombosis/therapy , Treatment OutcomeABSTRACT
BACKGROUND: COVID-19 due to SARS-CoV-2 was first described in the city of Wuhan in China and spread around the world turning into a pandemic. COVID-19 can affect different organ systems, including the oral mucosa. AIMS: Although cutaneous involvement has been defined in association with COVID-19, the number of case reports about mucosal involvement by SARS-CoV-2 is limited. Hereby, we report a case of hemorrhagic necrosis on the lip in a patient with paroxysmal nocturnal hemoglobinuria (PNH) and COVID-19 infection and briefly discuss its possible mechanism. PATIENTS: The clinical features and causes of hemorrhagic necrosis on the lip in a woman are presented. RESULTS: In our patient, we think that PNH-associated dermal micro-occlusions caused extensive painful necrosis of the lip. Additionally, COVID-19-induced endothelial damage helped to develop exaggerated hemorrhagic necrosis. CONCLUSION: This current case presentation will contribute to the literature as another case with COVID-19 triggering mucosal involvement.
Subject(s)
COVID-19/complications , Hemoglobinuria, Paroxysmal/complications , Lip/pathology , Aged , COVID-19/pathology , Female , Hemoglobinuria, Paroxysmal/pathology , Humans , Necrosis/diagnosis , Necrosis/etiology , Necrosis/therapyABSTRACT
Necrotizing pneumonia induced by Panton-Valentine leukocidin-secreting Staphylococcus aureus is a rare but life-threatening infection that has been described in patients after they had influenza. We report a fatal case of this superinfection in a young adult who had coronavirus disease.